Glial Regenerative Response and Experimental models of nervous system pathologies

My research centers on uncovering how glial cells orchestrate neurogenesis and tissue repair in the injured and diseased Central Nervous System (CNS). We investigate how glial cells maintain CNS homeostasis in a pathological context, and, more specifically, in an injury context, how glial cells generate new neurons in response to injury. A key question driving my work is: can we use this neurogenic capacity to slow down other neurodegenerative diseases such as ALS, AD, or Glioblastoma? I also explore how different glial cell types coordinate the glial regenerative response to injury, and how neurons and glia communicate in this context, with the ultimate goal of understanding and harnessing endogenous neurogenic programs to promote long-term functional recovery.